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Clinical Trials

Note: This document is prepared as a service for the ALS community and is intended as general information. Content used in this report is obtained from informed members of the pharmaceutical industry and the ALS community.

For further information on drug trials, ClinicalTrials.gov provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions. For an overview of clinical trials information, click here.

OPEN TRIALS

Compound or Trial	Status & Sites	Company or Center
Lithium	Now Enrolling	Massachusetts General Hospital
Arimoclomol	Now Enrolling	Emory University
Validation of ALS Biomarkers	Now Enrolling	Multi-center
Talampanel	Now Enrolling	Teva Pharmaceuticals, LTD
Electrical Impedence Myography	Now Enrolling	Beth Israel Deaconess
Tretinoin and Pioglitazone HCL Combination Therapy	Now Enrolling	Phoenix Neurological Associates
Major Depression in ALS	Now Enrolling	University of South Carolina
AVP-923 in PBA Patients	Now Enrolling	Multi-center
Quality of Life Survey	Enrollment Closed	Hershey ALS Clinic
Memantine Trial	Now Enrolling	University of Alberta
Trial for Familial ALS	Now Enrolling	Emory University
New Gene Study	Enrollment Open	University of Massachusetts Medical Center
Ceftriaxone	Now Enrolling	Northeast ALS Consortium
Memantine Therapy	Enrollment Closed	Banner Good Samaritan ALS Clinic

CLOSED TRIALS

Compound or Trial	Status	Company or Center
CL201 Study in ALS	Enrollment Closed	Multi-center
Tamoxifen	Enrollment Closed	The University of Wisconsin-Madison
Thalidomide	Enrollment Closed	Dartmouth-Hitchcock Medical Center
Diaphragm Training	Enrollment Closed	Beth Israel Deaconess Medical Center
National Registry of Veterans with ALS	Enrollment Closed	Durham, North Carolina VAMC
Combination Therapy Selection Trial in ALS	Enrollment Closed	Multicenter
Sodium Phenylbutyrate	Enrollment Closed	Multicenter
The Vest	Enrollment Closed	Hill-Rom
Creatine	Enrollment Closed	The Carolinas Neuromuscular/ALS Center
Myotrophin®	Study Completed	Cephalon
Celebrex	Study Completed	Northeast ALS Consortium
NEOTROFIN^TM	Study Completed	NeoTherapeutics, Inc.
NAALADase	Study Completed	Guilford Pharmaceuticals Inc.
Neurodex	Study Completed	Avanir Pharmaceuticals
Rilutek®	FDA approved drug currently available	Aventis S.A.
Oxandrolone	Study Completed	The Carolinas Neuromuscular/ALS MDA Center
Pilot CoQ10	Enrollment Closed	Eleanor and Lou Gehrig ALS Center at Columbia University
High Dose Coenzyme Q10	Enrollment Closed	The Eleanor and Lou Gehrig MDA/ALS Research Center
Pilot CoQ10 with imaging	Enrollment Closed	Eleanor and Lou Gehrig ALS Center at Columbia University
Topiramate (Topamax)	Study Completed	North Eastern ALS Consortium
Xaliproden	Preliminary analysis released 9/5/00	Sanofi-Synthelabo Inc.
Indinavir	Study Completed	Beth Israel Medical Center
Creatine	Study Completed	North Eastern ALS Consortium
Creatine	Study Completed	The West Virginia University School of Medicine
Minocycline Investigation	Enrollment Closed	Eleanor and Lou Gehrig ALS Center at Columbia University
Buspirone Investigation	Study Completed	Multicenter ALS

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